Comment on "Twisted Protein Aggregates and Disease: The Stability of Sickle Hemoglobin Fibers"

Abstract

Aggregates of twisted protein fibers, such as sickle hemoglobin and actin, are important examples of biopolymers in which elastic interactions play a crucial role in determining the (metastable) bundle radii. Here, we present a corrected version of analysis on the stability of sickle hemoglobin fibers using the classic nucleation theory.