Role of Antibodies: A Novel Paradigm in Mathematical Modeling for Cancer Treatment

Abstract

A mathematical model for the quantitative analysis of cancer immune interaction, considering the role of antibodies has been proposed in this paper. The model is based on the clinical evidence, which states that antibodies can directly kill cancerous cells [1]. The existence of transcritical and saddle-node bifurcation, which has been proved using Sotomayor theorem, provides strong biological implications. Through numerical simulations, it has been illustrated that under certain therapy (like monoclonal antibody therapy), which is capable of altering the parameters of the system, cancer-free state can be obtained.