The random release of phosphate controls the dynamic instability of microtubules

Abstract

A simple stochastic model which describes microtubule dynamics and explicitly takes into account the relevant biochemical processes is presented. The model incorporates binding and unbinding of monomers and random phosphate release inside the polymer. It is shown that this theoretical approach provides a microscopic picture of the dynamic instability phenomena of microtubules. The cap size, the concentration dependence of the catastrophe times and the delay before observing catastrophes following a dilution can be quantitatively predicted by this approach in a direct and simple way. Furthermore, the model can be solved analytically to a large extend, thus offering a valuable starting point for more refined studies of microtubules dynamics.