Covalent bond symmetry breaking and protein secondary structure

Abstract

Both symmetry and organized breaking of symmetry have a pivotal r\^ole in our understanding of structure and pattern formation in physical systems, including the origin of mass in the Universe and the chiral structure of biological macromolecules. Here we report on a new symmetry breaking phenomenon that takes place in all biologically active proteins, thus this symmetry breaking relates to the inception of life. The unbroken symmetry determines the covalent bond geometry of a sp3 hybridized carbon atom. It dictates the tetrahedral architecture of atoms around the central carbon of an amino acid. Here we show that in a biologically active protein this symmetry becomes broken. Moreover, we show that the pattern of symmetry breaking is in a direct correspondence with the local secondary structure of the folded protein.