Finite population size effects in quasispecies models with single-peak fitness landscape

Abstract

We consider finite population size effects for Crow-Kimura and Eigen quasispecies models with single peak fitness landscape. We formulate accurately the iteration procedure for the finite population models, then derive Hamilton-Jacobi equation (HJE) to describe the dynamic of the probability distribution. The steady state solution of HJE gives the variance of the mean fitness. Our results are useful for understanding population sizes of virus in which the infinite population models can give reliable results for the biological evolution problems.