Beyond Spikes: Neural Codes and the Chemical Vocabulary of Cognition

Abstract

In this paper, I examine what I refer to as the spike doctrine, which is the generally held belief in neuroscience that information in the brain is encoded by sequences of neural action potentials. I present the argument that specific neurochemicals, and not spikes, are the elementary units of information in the brain. I outline several predictions that arise from this interpretation, relate them to results in the current research literature, and show how they address some open questions.