Vitamin D sensitivity to the immune responses and autoimmunity: A chemical network model study

Abstract

Although Vitamin D is believed to be involved in a large number of immune responses our understanding of these processes at cellular level remained at infancy. We develop and solve a coarse grained kinetic network model to quantify the effects of variation of vitamin D on human immunity. The system of equations accounts for known inter-relation between active and inactive vitamin D, antigen presenting cells, effector T cells, regulatory T cells and pathogen. Both time dependent and steady state solutions are obtained. The time dependent solution of the system of equations reveals that the immune response is rather strongly regulated in presence of vitamin D. We found quantitatively that lower than optimum levels of concentration of active vitamin D correspond to weak regulation where, once a pathogen/antigen enters the body, the nature of the immune response would be less regulatory and hence more aggressive, or inflammatory. The steady state solution of our model shows that vitamin D enhances the tolerance level of immune system, thereby increasing resistance to autoimmune diseases. Our model and accompanied numerical analyses reveal another important aspect of immunity: While extremely low levels of vitamin D could lead to increased risk of autoimmune responses, an overdose (toxic) level would give rise to too large a tolerant response, leading to the increased risk of tumors and cancerous cell growth.