Lagerkvist versus Crick
Abstract
Present day data allow significant reconsideration of ideas on mechanisms underlying the degeneracy in the genetic code. Here a hypothesis is presented which links the degeneracy to possible conformational alterations in the codon-anticodon duplex. This enables explanation of Rumer symmetry in the table of the genetic code, coding of methionine and tryptophane without degeneracy and predict significant difference between thymine and uracyl. The suggested hypothesis has something in common with Lagerkvist idea that only two nucleotides in codon are coding.
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