The co-existence of states in p53 dynamics driven by miRNA

Abstract

The regulating mechanism of miRNA on p53 dynamics in p53-MDM2-miRNA model network incorporating reactive oxygen species (ROS) is studied. The study shows that miRNA drives p53 dynamics at various states, namely, stabilized states and oscillating states (damped and sustain oscillation). We found the co-existence of these states within certain range of the concentartion level of miRNA in the system. This co-existence in p53 dynamics is the signature of the system's survival at various states, normal, activated and apoptosis driven by a constant concentration of miRNA.