Stochastic synchronization of genetic oscillators induced by miRNA
Abstract
We study two important roles of miRNA as stress inducer and synchronizing agent in regulating diffusively coupled genetic oscillators within stochastic formalism and competition between them. We identify optimal value of coupling constant at which the rate of synchronization is strongest, below this value sychronizing activity dominates stress activity, and above it stress activity destroys synchronizing pattern. The concentration of miRNA maintained in individual oscillator modulates the synchronization activity achieved by diffusing miRNA.
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