Perturbation of a globally stable equilibrium: application on an age-structured model

Abstract

In this manuscript we consider an age structured epidemic system modelling the dynamics of transmission of immunizing disease like Hepatitis B virus. Our model takes into account age as well as two classes of infected individuals (chronic carriers and acute infected human). Based on the low infectivity of chronic carriers, we study the asymptotic behavior of the system and, under some suitable assumptions, we prove the global stability of the endemic equilibrium point using perturbation arguments of semi-flow. The intuitive conservation of the global stability under perturbation, needs in fact very technical tools and complex results.