Localized modulated wave solutions in diffusive glucose-insulin systems

Abstract

We investigate intercellular insulin dynamics in an array of diffusively coupled pancreatic islet \b{eta}-cells. The cells are connected via gap junction coupling, where nearest neighbor interactions are included. Through the multiple scale expansion in the semi-discrete approximation, we show that the insulin dynamics can be governed by the complex Ginzburg-Landau equation. The localized solutions of this equation are reported. The results suggest from the biophysical point of view that the insulin propagates in pancreatic islet \b{eta}-cells using both temporal and spatial dimensions in the form of localized modulated waves.