Estimating the number of tissue resident macrophages
Abstract
I provide a simple estimation for the number of macrophages in a tissue, arising from the hypothesis that they should keep infections below a certain threshold, above which neutrophils are recruited from blood circulation. The estimation reads Nm=a Ncelα/Nmax, where a is a numerical coefficient, the exponent α is near 2/3, and Nmax is the maximal number of pathogens a macrophage may engulf in the time interval, tr, between pathogen replications.
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