Catalytic Nucleation of Amyloid Beta and Hen Egg White Fibrils, and p53 Oligomerization

Abstract

Scaling theory generates transferable (even universal) algebraic and geometrical relations between the amino acid sequences and the aggregation functions of the three titled radically different proteins. In addition to the two hydropathicity scales and beta strand scales used in earlier p53 work, a second beta strand Hot Spot scale is shown to yield very accurate results for oligomerization of p53, the tumor suppressor. These algebraic and geometrical relations could be caused topologically by the dominance of protein-protein aggregation by interactions in a membrane catalytic surface layer.