A Simple Generic Model of Cellular Polarity Alignment: Derivation and Analysis

Abstract

Ordered polarity alignment of a cell population plays a vital role in biology, such as in hair follicle alignment and asymmetric cell division. Here, we propose a theoretical framework for the understanding of generic dynamical properties of polarity alignment in interacting cellular units, where each cell is described by a reaction-diffusion system and the cells further interact with one another through their proximal surfaces. The system behavior is shown to be strongly dependent on geometric properties such as cell alignment and cell shape. Using a perturbative method under the assumption of weak coupling between cells, we derive a reduced model in which each cell is described by just one variable, the phase. The reduced model resembles an XY model but contains novel terms that possesses geometric information, which enables the understanding of the geometric dependencies as well as the effects of external signal and noise. The model is simple, generic, and analytically and numerically tractable, and is therefore expected to facilitates studies on cellular polarity alignment in various nonequilibrium systems.