Dipole Incompatibility Related Artifacts in Quantitative Susceptibility Mapping

Abstract

Artifacts in quantitative susceptibility mapping (QSM) are analyzed to establish an optimal design criterion for QSM inversion algorithms. The magnetic field data is decomposed into two parts, dipole compatible and incompatible parts. The dipole compatible part generates the desired non-streaking solution. The dipole incompatible part, including noise, discretization error, and anisotropy sources, generates artifacts defined by a wave propagator with the B0 field direction as the time axis. Granular noise causes streaking and contiguous error causes both streaking and shadow artifacts. As an example, truncation-based QSM algorithms are inherently prone to streaking artifacts because of the deviation of the dipole kernel during truncation. Through numerical phantom and imaging experiments, several QSM methods, including a Bayesian regularization method and the k-space truncation methods, were compared to show that the Bayesian approach with a structural prior provides advantages in terms of both image quality and quantitative measures.