dbMPIKT: A web resource for the kinetic and thermodynamic database of mutant protein interactions

Abstract

Protein-protein interactions (PPIs) perform important roles on biological functions. Researches of mutants on protein interactions can further understand PPIs. In the past, many researchers have developed databases that stored mutants on protein interactions, which are old and not updated till now. To address the issue, we developed a kinetic and thermodynamic database of mutant protein interactions (dbMPIKT) that can be freely accessible at our website. This database contains 5291 mutants that integrated data from previous databases and data from literatures for nearly three years. Furthermore, the data were analyzed, involving mutation number, mutation type, protein pair source and network map construction. On the whole, the database provides new data to further improve the study on PPIs. Website: http://210.45.212.128/lqy/index.php