A tank-circuit for ultrafast single particle detection in micropores

Abstract

We present an ultrafast single sub-micron particle detection method based on a half-bowtie coplanar waveguide. The method is capable of resolving the translocation of these particles at a bandwidth greater than 30MHz. We compare experimentally the simultaneous use of our radio- frequency technique with conventional DC based resistive pulse recordings and find that our method has a throughput that is enhanced by two orders of magnitude. The technique incorporates a microfluidic circuit and has potential to be employed for screening nano particles and biopolymers such as DNA at frequencies in excess of 1 GHz.