Universality of macroscopic neuronal dynamics in Caenorhabditis elegans

Abstract

Recordings of whole brain activity with single neuron resolution are now feasible in simple organisms. Yet, it is still challenging to appropriately simplify such complex, noisy, and multivariate data in order to reveal general principles of nervous system function. Here, we develop a method that allows us to extract global brain dynamics from pan-neuronal imaging. Success of this method is rooted in a surprising mathematical connection between dimensionality reduction and a general class of thermodynamic systems. Application of this theoretical framework to the nervous system of C. elegans reveals the manifold that sculpts global brain dynamics. This manifold allows us to predict switches between worm behaviors across individuals, implying that macroscopic dynamics embodied by the manifold are universal. In contrast, activation of individual neurons differs consistently between worms. These findings suggest that brains of genetically identical individuals express distinct microscopic neuronal configurations which nonetheless yield equivalent macroscopic dynamics.