FastLORS: Joint Modeling for eQTL Mapping in R

Abstract

Yang et al. (2013) introduced LORS, a method that jointly models the expression of genes, SNPs, and hidden factors for eQTL mapping. LORS solves a convex optimization problem and has guaranteed convergence. However, it can be computationally expensive for large datasets. In this paper we introduce Fast-LORS which uses the proximal gradient method to solve the LORS problem with significantly reduced computational burden. We apply Fast-LORS and LORS to data from the third phase of the International HapMap Project and obtain comparable results. Nevertheless, Fast-LORS shows substantial computational improvement compared to LORS.