Thresholds and bistability in HIV infection models with oxidative stress

Abstract

Oxidative stress, a reaction caused by the imbalance between the reactive oxygen species of human organism and its ability to detoxify reactive intermediates and to repair the resulting damage plays an important role in HIV-infections. On one hand, HIV infection is responsible for the chronic oxidative stress of the patients. On the other hand, the oxidative stress contributions to the HIV disease pathogenesis. In this paper, we integrate oxidative stress into an HIV infection model to investigate its effects on the virus dynamics. Through mathematical analysis, we obtain the basic reproduction number R0 of the model which describes the persistence of viruses. In particular, we show that for R0 > 1, the model has a bistable interval with virus rebound threshold and elite control threshold. Numerical simulations and bifurcation analysis are presented to illustrate the viral dynamics under oxidative stress. Our investigation reveals the interplay between viruses and the reaction of human organism including immune response and oxidative stress, and their effects on the health of human being.