Magnetic Nanoparticles in Nanomedicine

Abstract

Nanomaterials, in addition to their small size, possess unique physicochemical properties that differ from the bulk materials, making them ideal for a host of novel applications. Magnetic nanoparticle (MNP) is one important class of nanomaterials that have been widely studied for their potential applications in nanomedicine. Due to the fact that MNPs can be detected and manipulated by remote magnetic fields, it opens a wide opportunity for them to be used in vivo. Nowadays, MNPs have been used for diverse applications including magnetic biosensing (diagnostics), magnetic imaging, magnetic separation, drug and gene delivery, and hyperthermia therapy, etc. This review aims to provide a comprehensive assessment of the state-of-the-art biological and biomedical applications of MNPs. In addition, the development of high magnetic moment MNPs with proper surface functionalization has progressed exponentially over the past decade. Herein, we also reviewed the recent advances in the synthesis and surface coating strategies of MNPs. This review is not only to provide in-depth insights into the different synthesis, biofunctionalization, biosensing, imaging, and therapy methods but also to give an overview of limitations and possibilities of each technology.