The possibility of blocking the process of DNA base pairs opening by hydrogen peroxide
Abstract
One of the most progressive methods of cancer treatment is ion beam therapy. The simulations of water radiolysis show that in the cell medium the most long-living species are hydrogen peroxide (H2O2) molecules. But up to the present time the role of H2O2 molecules in the deactivation of cancer cells has not been determined yet. To understand the possible role of H2O2 in ion beam therapy, the competitive interaction of H2O2 and H2O molecules with nucleic bases in a pair on the different stages of genetic information transfer is studied in the present work. Atom-atomic potential functions method is used for the calculations. It is shown, that some configurations of AT and GC complementary pairs are stabilized much better by H2O2 molecule compared to water molecule. Formation of such interaction complexes can terminate the processes of DNA unzipping by enzymes and consequently block genetic information transfer processes in cancer cells during ion beam therapy treatment. Experimental verification method of hydrogen peroxide interaction with nucleic base pairs is proposed.
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