Short-Range Migration Can Alter Evolutionary Dynamics in Solid Tumors

Abstract

Here, we investigate how competition in the Eden model is affected by short range dispersal and the requirement that site updates occur only after several updates of the same site have been attempted previously. The latter models the effect of tissue or media resistance to invasion. We found that the existence of tissue intensifies 'Natural Selection' and de-accelerating 'Genetic Drift', both to a limited extent. More interestingly, our results show that short-range migration can eliminate Genetic demixing and conceal Natural Selection.