Tracking the Effects of Cancer on Microtubule Dynamic Instability

Abstract

Dynamic instability in the cytoskeleton underlies a great many vital cellular processes. In neurons, it is thought to play a role in information processing and the establishment of synaptic connections. It is from this interneuronal connectivity that the large-scale organization and function of the brain ultimately emerges. While brain networks above the cellular scale have been extensively investigated with medical imaging, no research has yet examined the contribution of the dynamic architecture subserving the components of these networks to their functionality. Simultaneous functional imaging at molecular and whole-brain scales may yield more comprehensive knowledge of this entailment. Procedures of statistical analysis based on a recently developed nonlinear model of microtubule dynamics are proposed to verify predictions about the spatiotemporal relationships between various microtubule-associated protein activities and functional connectivity. Known effects of brain cancer on functional connectivity and peritumoral complexity serve as the basis for a comparative study of these phenomena in regions of interest with particularly high and low complexity.