Emerging classes of antioxidant to cancer therapy: a review of clinical and experimental studies

Abstract

This review mainly focuses on the relation between antioxidants with cancer therapy. Antioxidants have been reported to play an essential role to reduce free radical species. Free radicals commonly cause oxidative damage which is a common factor in the aging process, and also the vital factor of formation, and development of major disease specially cancer. Although, since last many decades several antioxidants belong to natural and synthetic origin have been tested in clinical trials against oxidative stress, however these clinical trials end up with undesirable effects. This review also complied with the most recent findings of oxidative stress, highlighting of free racial production, and its related oxidative damage at cellular and molecular level, with the new and existing natural and synthetic classes of free radical scavenger and their related clinical trials.