LOOPER: Inferring computational algorithms enacted by neuronal population dynamics

Abstract

Recording simultaneous activity of hundreds of neurons is now possible. Existing methods can model such population activity, but do not directly reveal the computations used by the brain. We present a fully unsupervised method that models neuronal activity and reveals the computational strategy. The method constructs a topological model of neuronal dynamics consisting of interconnected loops. Transitions between loops mark computationally-salient decisions. We accurately model activation of 100s of neurons in the primate cortex during a working memory task. Dynamics of a recurrent neural network (RNN) trained on the same task are topologically identical suggesting that a similar computational strategy is used. The RNN trained on a modified dataset, however, reveals a different topology. This topology predicts specific novel stimuli that consistently elicit incorrect responses with near perfect accuracy. Thus, our methodology yields a quantitative model of neuronal activity and reveals the computational strategy used to solve the task.