A framework for modeling cells spreading, motility and the relocation of proteins on advecting lipid membranes
Abstract
The response of cells during spreading and motility is dictated by several multi-physics events, which are triggered by extracellular cues and occur at different time-scales. For this sake, it is not completely appropriate to provide a cell with classical notions of the mechanics of materials, as for "rheology" or "mechanical response". Rather, a cell is an alive system with constituents that show a reproducible response, as for the contractility for single stress fibers or for the mechanical response of a biopolymer actin network, but that reorganize in response to external cues in a non-exactly-predictable and reproducible way. Aware of such complexity, in this note we aim at formulating a multi-physics framework for modeling cells spreading and motility, accounting for the relocation of proteins on advecting lipid membranes.