Temperature effect on the cardiac ryanodine receptor gating and conductance: mathematical modelling

Abstract

The temperature effect on the cardiac ryanodine receptor (RyR) function has been studied within the electron-conformational (EC) model. It is shown that simple EC model with the Arrhenius like temperature dependence of "internal" and "external" frictions and a specific thermosensitivity of the tunnelling "open - close" transitions can provide both qualitative and quantitative description of the temperature effects for isolated RyRs. The potential of the model was illustrated by explaining the experimental data on the temperature dependence of sheep's isolated cardiac RyR gating and conductance (R. Sitsapesan et al., J Physiol 434, 469 (1991)).