Local Field Potential Journey into the Basal Ganglia

Abstract

Local Field potential (LFP) in the basal ganglia (BG) nuclei in the brain have attracted much research and clinical interest. However, the origin of this signal is still under debate throughout the last decades. The question is whether it is a local subthreshold phenomenon, synaptic input to neurons or it is a flow of electrical signals merged as volume conduction which are generated from simultaneous firing neurons in the cerebral cortex and obeys the Maxwell equations. In this study, we recorded in a monkey brain simultaneously LFP's from the cerebral cortex, in the frontal lobe and primary motor cortex (M1) and in sites in all BG nuclei: the striatum, globus pallidus, and subthalamic nucleus. All the records were taken from human primate model (vervet monkey), during spontaneous activity. Developing and applying a novel method to identify significant cross-correlations (potential links) while removing "spurious" correlations, we found a tool that may discriminate between the two major phenomena of synaptic inputs (as we define as information flow) and volume conduction. We find mainly two major paths flows of field potential, that propagates with two different time delays, from the primary motor cortex, and from the frontal cortex. Our results indicate that the two path flows may represent the two mechanisms of volume conduction and information flow.