A parameter study on optimal scaffolds in a simple model for bone regeneration

Abstract

We propose a simple model for scaffold aided bone regeneration. In this model, only macroscopic quantities, e.g., locally averaged osteoblast densities, are considered. This allows for use of this model in an optimization algorithm, whose outcome is an optimal scaffold porosity distribution. This optimal scaffold naturally depends on the choice of parameters in the model, and we provide a parameter study with a particular focus on patients with reduced bone regeneration or reduced vascularization capacity.