A mean-field theory approach to 3D nematic phase transitions in microtubules

Abstract

Microtubules are dynamic intracellular fibers that have been observed experimentally to undergo spontaneous self-alignment. We formulate a 3D mean-field theory model to analyze the nematic phase transition of microtubules growing and interacting within a 3D space then make a comparison with computational simulations. We identify a control parameter $G_\text{eff}$ and predict a unique critical value $G_\text{eff}=1.56$ for which a phase transition can occur. Furthermore, we show both analytically and using simulations that this predicted critical value does not depend on the presence of zippering. The mean-field theory developed here provides an analytical estimate of microtubule patterning characteristics without running time-consuming simulations and is a step towards bridging scales from microtubule behavior to multicellular simulations.