Geometric singular perturbation analysis of the multiple-timescale Hodgkin-Huxley equations

Abstract

We present a novel and global three-dimensional reduction of a non-dimensionalised version of the four-dimensional Hodgkin-Huxley equations [J. Rubin and M. Wechselberger, Giant squid--hidden canard: the 3D geometry of the Hodgkin-Huxley model, Biological Cybernetics, 97 (2007), pp. 5--32] that is based on geometric singular perturbation theory (GSPT). We investigate the dynamics of the resulting three-dimensional system in two parameter regimes in which the flow evolves on three distinct timescales. Specifically, we demonstrate that the system exhibits bifurcations of oscillatory dynamics and complex mixed-mode oscillations (MMOs), in accordance with the geometric mechanisms introduced in [P. Kaklamanos, N. Popovi\'c, and K. U. Kristiansen, Bifurcations of mixed--mode oscillations in three--timescale systems: An extended prototypical example, Chaos: An Interdisciplinary Journal of Nonlinear Science, 32 (2022), p. 013108], and we classify the various firing patterns in terms of the external applied current. While such patterns have been documented in [S. Doi, S. Nabetani, and S. Kumagai, Complex nonlinear dynamics of the Hodgkin-Huxley equations induced by time scale changes, Biological Cybernetics, 85 (2001), pp. 51--64] for the multiple-timescale Hodgkin-Huxley equations, we elucidate the geometry that underlies the transitions between them, which had not been previously emphasised.