Fast Exact String to D-Texts Alignments

Abstract

In recent years, aligning a sequence to a pangenome has become a central problem in genomics and pangenomics. A fast and accurate solution to this problem can serve as a toolkit to many crucial tasks such as read-correction, Multiple Sequences Alignment (MSA), genome assemblies, variant calling, just to name a few. In this paper we propose a new, fast and exact method to align a string to a D-string, the latter possibly representing an MSA, a pan-genome or a partial assembly. An implementation of our tool dsa is publicly available at https://github.com/urbanslug/dsa