Metabolomics of Aging and Alzheimer's Disease: From Single-Omics to Multi-Omics

Abstract

Aging is a multifactorial process and a key factor of morbidity and mortality. Alzheimer's disease (AD) is an age-related disorder and a main cause of worldwide disability. Both aging and AD can be characterized by metabolic dysfunction. Metabolomics can quantify the complete set of metabolites in a studied sample and is helpful for studying metabolic alterations in aging and AD. In this review, we summarize the metabolomic changes regarding aging and AD, discuss their biological functions, and highlight their potential application as diagnostic biomarkers or therapeutic targets. Recent advances in multi-omics approaches for understanding the metabolic mechanism of aging and AD are also reviewed.