$\ell_1$-penalized Multinomial Regression: Estimation, inference, and prediction, with an application to risk factor identification for different dementia subtypes

Abstract

High-dimensional multinomial regression models are very useful in practice but have received less research attention than logistic regression models, especially from the perspective of statistical inference. In this work, we analyze the estimation and prediction error of the contrast-based $\ell_1$-penalized multinomial regression model and extend the debiasing method to the multinomial case, providing a valid confidence interval for each coefficient and $p$-value of the individual hypothesis test. We also examine cases of model misspecification and non-identically distributed data to demonstrate the robustness of our method when some assumptions are violated. We apply the debiasing method to identify important predictors in the progression into dementia of different subtypes. Results from extensive simulations show the superiority of the debiasing method compared to other inference methods.