Quantitative characterization of amyloid deposits in murine models of alzheimer disease by phase-contrast x-ray imaging

Abstract

Alzheimer's is a neurodegenerative disease that is the most common form of dementia, but there is still no definitive cure for this disease. The noninvasive X-ray Phase Contrast Tomography (XPCT) imaging technique was used to study brain tissues in mouse models of Alzheimer's disease, AP-PS1 and APP23. The XPCT technique enabled high-resolution imaging of brain tissues, distinguishing between different brain structures, such as amyloid deposits and neuronal cells. In addition, the XPCT technique provided detailed information on the distribution and morphology of amyloid deposits in AP-PS1 and APP23 mice putting in evidence the differences between these two models. This work demonstrates the effectiveness of this technique in supporting Alzheimer's studies and evaluating new therapeutic strategies.