MulMarker: a comprehensive framework for identifying multi-gene prognostic signatures

Abstract

Prognostic signatures play an important role in clinical research, offering insights into the potential health outcomes of patients and guiding therapeutic decisions. Although single-gene prognostic biomarkers are valuable, multi-gene prognostic signatures offer deeper insights into disease progression. In this paper, we propose MulMarker, a comprehensive framework for identifying multi-gene prognostic signatures across various diseases. MulMarker comprises three core modules: a chatbot for addressing user queries, a module for identifying multi-gene prognostic signatures, and a module for generating tailored reports. Employing MulMarker, we identified a cell cycle-related prognostic signature that consists of CCNA1/2, CCNB1/2/3, CCNC, CCND1/2/3, CCNE1/2, CCNF, CCNG1/2, and CCNH. Based on the prognostic signature, we successfully stratified patients into high-risk and low-risk groups. Notably, our analysis revealed that patients in the low-risk group demonstrated a significantly higher survival rate compared to those in the high-risk group. Overall, MulMarker represents an efficient approach for the identification of multi-gene prognostic signatures. We release the code of MulMarker at https://github.com/Tina9/MulMarker.