Sensitivity models and bounds under sequential unmeasured confounding in longitudinal studies

Abstract

Consider sensitivity analysis to assess the worst-case possible values of counterfactual outcome means and average treatment effects under sequential unmeasured confounding in a longitudinal study with time-varying treatments and covariates. We formulate several multi-period sensitivity models to relax the corresponding versions of the assumption of sequential unconfounding. The primary sensitivity model involves only counterfactual outcomes, whereas the joint and product sensitivity models involve both counterfactual covariates and outcomes. We establish and compare explicit representations for the sharp and conservative bounds at the population level through convex optimization, depending only on the observed data. These results provide for the first time a satisfactory generalization from the marginal sensitivity model in the cross-sectional setting.