Comparative Analysis of Radiomic Features and Gene Expression Profiles in Histopathology Data Using Graph Neural Networks

Abstract

This study leverages graph neural networks to integrate MELC data with Radiomic-extracted features for melanoma classification, focusing on cell-wise analysis. It assesses the effectiveness of gene expression profiles and Radiomic features, revealing that Radiomic features, particularly when combined with UMAP for dimensionality reduction, significantly enhance classification performance. Notably, using Radiomics contributes to increased diagnostic accuracy and computational efficiency, as it allows for the extraction of critical data from fewer stains, thereby reducing operational costs. This methodology marks an advancement in computational dermatology for melanoma cell classification, setting the stage for future research and potential developments.