Enhancing Hemodynamic Parameter Estimations: Nonlinear Blood Behavior in 4D Flow MRI
Abstract
Hemodynamic parameters are often estimated assuming a constant Newtonian viscosity, even though blood exhibits shear-thinning behavior. This article investigates the influence of blood rheology and hematocrit (Hct) percentage on the estimation of Wall Shear Stress (WSS), rate of viscous Energy Loss (EL) at different points in the cardiac cycle, and the Oscillatory Shear Index (OSI). We focus on a hematocrit-dependent power-law non-Newtonian model, considering a wide range of Hct values at physiological temperature, with rheological parameters obtained from previously reported experimental data. In all cases, we systematically compared WSS, EL, and OSI using both Newtonian and power-law models, underscoring the crucial role of blood rheology in accurately assessing cardiovascular diseases. Our results show that, in in-silico experiments, differences in WSS and EL across a wide range of Hct values can reach as high as 190\% and 113\% at systole, and as low as -72\% and -74\% at diastole, respectively. In in-vivo data, differences in WSS and EL can reach up to -45\% and -60\% at systole, and range from -69\% to 73\% at diastole. This study enhances our understanding of the impact of blood rheology on hemodynamic parameter estimations using both in-silico and in-vivo aortic 4D Flow MRI data.