A whole-body mathematical model of cholesterol metabolism and transport

Abstract

Cardiovascular diseases are the leading cause of death. Increased levels of plasma cholesterol are consistently associated with an increased risk of cardiovascular disease. As a result, it is imperative that studies are conducted to determine the best course of action to reduce whole-body cholesterol levels. A whole-body mathematical model for cholesterol metabolism and transport is proposed. The model can simulate the effects of lipid-lowering drugs like statins and anti-PCSK9. The model is based on ordinary differential equations and kinetic functions. It has been validated against literature data. It offers a versatile platform for designing personalized interventions for cardiovascular health management.