Assessing Generalization Capabilities of Malaria Diagnostic Models from Thin Blood Smears

Abstract

Malaria remains a significant global health challenge, necessitating rapid and accurate diagnostic methods. While computer-aided diagnosis (CAD) tools utilizing deep learning have shown promise, their generalization to diverse clinical settings remains poorly assessed. This study evaluates the generalization capabilities of a CAD model for malaria diagnosis from thin blood smear images across four sites. We explore strategies to enhance generalization, including fine-tuning and incremental learning. Our results demonstrate that incorporating site-specific data significantly improves model performance, paving the way for broader clinical application.