Hallucination Detection in Virtually-Stained Histology: A Latent Space Baseline

Abstract

Histopathologic analysis of stained tissue remains central to biomedical research and clinical care. Virtual staining (VS) offers a promising alternative, with potential to reduce costs and streamline workflows, yet hallucinations pose serious risks to clinical reliability. Here, we formalize the problem of hallucination detection in VS and propose a scalable post-hoc method: Neural Hallucination Precursor (NHP), which leverages the generator's latent space to preemptively flag hallucinations. Extensive experiments across diverse VS tasks show NHP is both effective and robust. Critically, we also find that models with fewer hallucinations do not necessarily offer better detectability, exposing a gap in current VS evaluation and underscoring the need for hallucination detection benchmarks.