Addressing Intersectionality, Explainability, and Ethics in AI-Driven Diagnostics: A Rebuttal and Call for Transdiciplinary Action

Abstract

The increasing integration of artificial intelligence (AI) into medical diagnostics necessitates a critical examination of its ethical and practical implications. While the prioritization of diagnostic accuracy, as advocated by Sabuncu et al. (2025), is essential, this approach risks oversimplifying complex socio-ethical issues, including fairness, privacy, and intersectionality. This rebuttal emphasizes the dangers of reducing multifaceted health disparities to quantifiable metrics and advocates for a more transdisciplinary approach. By incorporating insights from social sciences, ethics, and public health, AI systems can address the compounded effects of intersecting identities and safeguard sensitive data. Additionally, explainability and interpretability must be central to AI design, fostering trust and accountability. This paper calls for a framework that balances accuracy with fairness, privacy, and inclusivity to ensure AI-driven diagnostics serve diverse populations equitably and ethically.