Sample size determination for machine learning in medical research

Abstract

Machine learning (ML) methods are being increasingly used across various domains of medicine research. However, despite advancements in the use of ML in medicine, clear and definitive guidelines for determining sample sizes in medical ML research are lacking. This article proposes a method for determining sample sizes for medical research utilizing ML methods, beginning with the determination of the testing set sample size, followed with the determination of the training set and total sample sizes.