Quantifying Diagnostic Signal Decay in Dementia: A National Study of Medicare Hospitalization Data

Abstract

Background: Artificial intelligence (AI) models in healthcare depend on the fidelity of diagnostic data, yet the quality of such data is often compromised by variability in clinical documentation practices. In dementia, a condition already prone to diagnostic ambiguity, this variability may introduce systematic distortion into claims-based research and AI model development. Methods: We analyzed Medicare Part A hospitalization data from 2016-2018 to examine patterns of dementia-related ICD-10 code utilization across more than 3,000 U.S. counties. Using a clinically informed classification of 17 ICD-10 codes grouped into five diagnostic categories, we applied the transitive Sequential Pattern Mining (tSPM+) algorithm to model temporal usage structures. We then used matrix similarity methods to compare local diagnostic patterns to national norms and fit multivariable linear regressions to identify county-level demographic and structural correlates of divergence. Findings: We found substantial geographic and demographic variation in dementia-related diagnostic code usage. Non-specific codes were dominant nationwide, while Alzheimer's disease and vascular dementia codes showed pronounced variability. Temporal sequence analysis revealed consistent transitions from specific to non-specific codes, which suggest degradation of diagnostic specificity over time. Counties with higher proportions of rural residents, Medicaid-eligible patients, and Black or Hispanic dementia patients demonstrated significantly lower similarity to national usage patterns. Our model explained 38% of the variation in local-to-national diagnostic alignment.