ConfAgents: A Conformal-Guided Multi-Agent Framework for Cost-Efficient Medical Diagnosis

Abstract

The efficacy of AI agents in healthcare research is hindered by their reliance on static, predefined strategies. This creates a critical limitation: agents can become better tool-users but cannot learn to become better strategic planners, a crucial skill for complex domains like healthcare. We introduce HealthFlow, a self-evolving AI agent that overcomes this limitation through a novel meta-level evolution mechanism. HealthFlow autonomously refines its own high-level problem-solving policies by distilling procedural successes and failures into a durable, strategic knowledge base. To anchor our research and facilitate reproducible evaluation, we introduce EHRFlowBench, a new benchmark featuring complex, realistic health data analysis tasks derived from peer-reviewed clinical research. Our comprehensive experiments demonstrate that HealthFlow's self-evolving approach significantly outperforms state-of-the-art agent frameworks. This work marks a necessary shift from building better tool-users to designing smarter, self-evolving task-managers, paving the way for more autonomous and effective AI for scientific discovery.