AI-Assisted Geometric Analysis of Cultured Neuronal Networks: Parallels with the Cosmic Web

Abstract

Building on evidence of structural parallels between brain networks and the cosmic web [1], we apply AI-based geometric analysis to cultured neuronal networks. Isolated neurons self-organize into dendritic lattices shaped by reproducible wiring rules. These lattices show non-random features-frequent dendritic convergence, hub nodes, small-world connectivity, and large voids. Synaptic contacts cluster and strengthen at hubs. Strikingly, these properties mirror the cosmic web: dendritic branches resemble cosmic filaments and synapses map to galaxies. Quantitative metrics align across systems, suggesting shared underlying geometric principles. We invite cross-disciplinary collaboration to interrogate and extend these parallels.