Pseudo-Bayesian Optimal Designs for Fitting Fractional Polynomial Response Surface Models

Abstract

Fractional polynomial models are potentially useful for response surfaces investigations. With the availability of routines for fitting nonlinear models in statistical packages they are increasingly being used. However, as in all experiments the design should be chosen such that the model parameters are estimated as efficiently as possible. The design choice for such models involves the known nonlinear models' design difficulties but \cite{gilmour_trinca_2012b} proposed a methodology capable of producing exact designs that makes use of the computing facilities available today. In this paper, we use this methodology to find Bayesian optimal exact designs for several fractional polynomial models. The optimum designs are compared to various standard designs in response surface problems.